1 From the Department of Anaesthesia, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban South Africa (MR); Perioperative Research Group, Department of Anaesthesia, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, and Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA (BMB); and Perioperative Research Group, Department of Anaesthesia, Grey's Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg, South Africa, and Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA (RNR).