Single-Cell Genomics for Virology

Viruses. 2016 May 4;8(5):123. doi: 10.3390/v8050123.

Abstract

Single-cell sequencing technologies, i.e., single cell analysis followed by deep sequencing investigate cellular heterogeneity in many biological settings. It was only in the past year that single-cell sequencing analyses has been applied in the field of virology, providing new ways to explore viral diversity and cell response to viral infection, which are summarized in the present review.

Keywords: RNA-Seq; cell-to-cell variability; genomics; heterogeneity; microfluidics; proteomics; sequencing; single cell; transcriptomics; virus.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genomics / methods*
  • Host-Pathogen Interactions*
  • Humans
  • Single-Cell Analysis / methods*
  • Virology / methods*
  • Viruses / immunology*
  • Viruses / pathogenicity*