Complete Genome Sequence of Streptomyces venezuelae ATCC 15439, Producer of the Methymycin/Pikromycin Family of Macrolide Antibiotics, Using PacBio Technology

Jingxuan He; Anitha Sundararajan; Nicholas P Devitt; Faye D Schilkey; Thiruvarangan Ramaraj; Charles E Melançon 3rd

doi:10.1128/genomeA.00337-16

Complete Genome Sequence of Streptomyces venezuelae ATCC 15439, Producer of the Methymycin/Pikromycin Family of Macrolide Antibiotics, Using PacBio Technology

Genome Announc. 2016 May 5;4(3):e00337-16. doi: 10.1128/genomeA.00337-16.

Authors

Jingxuan He¹, Anitha Sundararajan², Nicholas P Devitt², Faye D Schilkey², Thiruvarangan Ramaraj³, Charles E Melançon 3rd⁴

Affiliations

¹ Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, USA.
² National Center for Genome Resources (NCGR), Santa Fe, New Mexico, USA.
³ National Center for Genome Resources (NCGR), Santa Fe, New Mexico, USA Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA.
⁴ Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, USA Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA Center for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico, USA cemelanc@unm.edu.

Abstract

Here, we report the complete genome sequence of Streptomyces venezuelae ATCC 15439, a producer of the methymycin/pikromycin family of macrolide antibiotics and a model host for natural product studies, obtained exclusively using PacBio sequencing technology. The 9.03-Mbp genome harbors 8,775 genes and 11 polyketide and nonribosomal peptide natural product gene clusters.

Grants and funding

P20 GM103451/GM/NIGMS NIH HHS/United States