Abstract
Phthalimidoacetyl isothiocyanate underwent addition-cyclization reactions with some nitrogen and carbon nucleophilic reagents. Simultaneous or subsequent cyclization of the obtained adducts gave target heterocyclic systems such as 1,2,4-triazoles, 1,3-diazines, 1,3-oxazines and thiourea attached to a phthalimido moiety. The antimicrobial activity of the synthesized compounds was tested.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Aspergillus flavus / drug effects
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Candida albicans / drug effects
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Cyclization
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds / pharmacology*
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Isothiocyanates / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Phthalimides / chemistry*
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Salmonella typhi / drug effects
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Heterocyclic Compounds
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Isothiocyanates
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Phthalimides