Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens

Markus von Schaewen; Gabriela Hrebikova; Alexander Ploss

doi:10.1007/978-1-4939-3661-8_5

Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens

Methods Mol Biol. 2016:1438:79-101. doi: 10.1007/978-1-4939-3661-8_5.

Authors

Markus von Schaewen¹, Gabriela Hrebikova¹, Alexander Ploss²

Affiliations

¹ Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
² Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA. aploss@princeton.edu.

PMID: 27150085
DOI: 10.1007/978-1-4939-3661-8_5

Abstract

Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.

Keywords: DMPK; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human liver chimeric mice; Humanized mice; Malaria; Viral hepatitis.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Cryopreservation
Disease Models, Animal
Hepatocytes / cytology
Hepatocytes / transplantation*
Humans
Liver / cytology*
Liver / growth & development
Liver Regeneration
Mice
Transplantation Chimera / growth & development*
Transplantation, Heterologous

Abstract

Publication types

MeSH terms

Grants and funding