Abstract
New drimane-type sesquiterpene cryptoporol A (1), cryptoporic acid derivative 6'-cryptoporic acid E methyl ester (2), and pseudouridine derivative cryptoporine A (3), as well as a known ergosterol 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (4), were isolated from a 90 % alcohol extract of the fruiting bodies of Cryptoporus volvatus. The structures of these compounds were established by spectroscopic analysis and circular dichroism. 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (4) exhibited antiviral activity against porcine reproductive and respiratory syndrome virus, and all compounds showed weak antioxidant activities.
Keywords:
Antiviral activity; Cryptoporic acid derivative; Cryptoporus volvatus; Pseudouridine derivative; Sesquiterpene.
MeSH terms
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Animals
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Antiviral Agents / chemistry*
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Biphenyl Compounds / chemistry
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Cell Line
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Chlorocebus aethiops
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Coriolaceae / chemistry*
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Drug Discovery / methods*
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Free Radicals / chemistry
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Fruiting Bodies, Fungal / chemistry
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Molecular Structure
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Picrates / chemistry
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Porcine respiratory and reproductive syndrome virus / drug effects
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Pseudouridine / chemistry*
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Pseudouridine / isolation & purification
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Pseudouridine / pharmacology
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Antioxidants
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Antiviral Agents
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Biphenyl Compounds
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Free Radicals
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Picrates
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Sesquiterpenes
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Pseudouridine
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1,1-diphenyl-2-picrylhydrazyl