Regio- and Stereoselective Copper(II)-Catalyzed Hydrosilylation of Activated Allenes in Water: Access to Vinylsilanes

Org Lett. 2016 May 20;18(10):2443-6. doi: 10.1021/acs.orglett.6b00981. Epub 2016 May 4.

Abstract

By using catalytic amounts of copper(II), 4-picoline, and dimethylphenylsilylpinacol borane, a series of allenoates were silylated on the β carbon in good to excellent yields and high (E)-selectivity. The mild and efficient silylation method is conducted in water under atmospheric conditions to afford vinylsilanes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.