The level of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1α) in human blood plasma was investigated. Samples of healthy individuals (n=34) and patients with cardiovascular diseases (n=110), including aortic aneurysm (n=69), aortic stenosis (n=25) and patients without aortic pathologies were analyzed. In patients the PGC1α concentration was higher than that in healthy persons, and tended to decrease with age. Elevated concentrations of lactic acid, total homocysteine and asymmetric dimethylarginine in the blood of patients suggested a parallel development of endothelial and secondary mitochondrial dysfunction. However, concentrations of lactic and pyruvic acids exceeding reference limit were associated with the decrease in the PGC1α level.
Vpervye provedeno issledovanie urovnia belka PGC1a (1a-koaktivatora gamma-retseptora, aktiviruiushchego proliferatsiiu peroksisom) v plazme krovi. Issledovany obraztsy zdorovykh lits (n=34) i patsientov s serdechno- sosudistymi zabolevaniiami (n=110), v tom chisle s anevrizmoĭ aorty (n=69), s aortal'nym stenozom (n=25) i bez patologii aorty. V gruppe patsientov kontsentratsiia PGC1a byla vyshe, chem u zdorovykh lits, i imela tendentsiiu k snizheniiu s vozrastom. Povyshennye kontsentratsii molochnoĭ kisloty, obshchego gomotsisteina i asimmetrichnogo dimetilarginina v krovi patsientov svidetel'stvovali o parallel'nom narastanii éndotelial'noĭ i vtorichnoĭ mitokhondrial'noĭ disfunktsiĭ. Na fone kontsentratsiĭ molochnoĭ i pirovinogradnoĭ kislot vyshe referentnykh znacheniĭ obnaruzheno snizhenie kontsentratsii PGC1a.
Keywords: PGC1a; blood plasma; diagnostics of mitochondrial dysfunction; endothelial dysfunction; lactic acid; pyruvic acid.