New expectations in the treatment of anemia in chronic kidney disease

Nefrologia. 2016 May-Jun;36(3):232-6. doi: 10.1016/j.nefro.2016.03.006. Epub 2016 Apr 29.
[Article in English, Spanish]

Abstract

The new drugs developed for the treatment of anemia in chronic kidney disease patients, together with their mechanisms of action are reviewed. At present, many of them are already in advanced stages of clinical trials and is expected to be incorporated into the therapeutic arsenal in the coming years. The potential benefits and possible limitations are also described.

Keywords: Anemia; Chronic kidney disease; Enfermedad renal crónica; Hepcidin; Hepcidina; Inhibidores de prolil-hidroxilasa; Prolyl-hidroxilase inhibitors; Sotatercept.

Publication types

  • Review

MeSH terms

  • Activins / antagonists & inhibitors
  • Anemia / drug therapy*
  • Anemia / etiology
  • Basic Helix-Loop-Helix Transcription Factors / physiology
  • Clinical Trials as Topic
  • Drugs, Investigational / therapeutic use
  • Erythropoiesis / drug effects
  • Erythropoietin / physiology
  • GATA Transcription Factors / antagonists & inhibitors
  • GATA Transcription Factors / physiology
  • Hematinics / classification
  • Hematinics / pharmacology
  • Hematinics / therapeutic use*
  • Hepcidins / antagonists & inhibitors
  • Humans
  • Multicenter Studies as Topic
  • Prolyl-Hydroxylase Inhibitors / pharmacology
  • Prolyl-Hydroxylase Inhibitors / therapeutic use
  • Randomized Controlled Trials as Topic
  • Receptors, Erythropoietin / agonists
  • Renal Dialysis / adverse effects
  • Renal Insufficiency, Chronic / blood
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / therapy

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Drugs, Investigational
  • EPO protein, human
  • GATA Transcription Factors
  • HAMP protein, human
  • Hematinics
  • Hepcidins
  • Prolyl-Hydroxylase Inhibitors
  • Receptors, Erythropoietin
  • Activins
  • Erythropoietin
  • endothelial PAS domain-containing protein 1