Ultrasmall Biocompatible WO3- x Nanodots for Multi-Modality Imaging and Combined Therapy of Cancers

Ling Wen; Ling Chen; Shimin Zheng; Jianfeng Zeng; Guangxin Duan; Yong Wang; Guanglin Wang; Zhifang Chai; Zhen Li; Mingyuan Gao

doi:10.1002/adma.201506428

Ultrasmall Biocompatible WO3- x Nanodots for Multi-Modality Imaging and Combined Therapy of Cancers

Adv Mater. 2016 Jul;28(25):5072-9. doi: 10.1002/adma.201506428. Epub 2016 May 2.

Authors

Ling Wen^{1

2}, Ling Chen^{1

2}, Shimin Zheng^{1

2}, Jianfeng Zeng^{1

2}, Guangxin Duan^{1

2}, Yong Wang^{1

2}, Guanglin Wang^{1

2}, Zhifang Chai^{1

2}, Zhen Li^{1

2}, Mingyuan Gao^{1

2

3}

Affiliations

¹ Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 215123, P. R. China.
² Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, P. R. China.
³ Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhongguancun, Beijing, 100190, P. R. China.

PMID: 27136070
DOI: 10.1002/adma.201506428

Abstract

Ultrasmall biocompatible WO3 - x nanodots with an outstanding X-ray radiation sensitization effect are prepared, and demonstrated to be applicable for multi-modality tumor imaging through computed tomography and photoacoustic imaging (PAI), and effective cancer treatment combining both photothermal therapy and radiation therapy.

Keywords: combined tumor therapy; multi-modality imaging; radiation sensitization; tungsten oxide; ultrasmall nanodots.

MeSH terms

Humans
Multimodal Imaging
Nanostructures
Neoplasms
Phototherapy
Tomography, X-Ray Computed
Tungsten / chemistry*

Substances

Tungsten