Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor

Andreia Latanza Gomes Mathez; Debora Moroto; Sergio Atala Dib; Joao Roberto de Sa

doi:10.1186/s13098-016-0148-2

Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor

Diabetol Metab Syndr. 2016 Apr 29:8:33. doi: 10.1186/s13098-016-0148-2. eCollection 2016.

Authors

Andreia Latanza Gomes Mathez¹, Debora Moroto¹, Sergio Atala Dib¹, Joao Roberto de Sa¹

Affiliation

¹ Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP Brazil.

Abstract

A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. This report describes a case of a patient with hypoinsulinemic hypoglycemia and Leser-Trélat sign associated with a malignant solitary fibrous tumor with IGF2 secretion. Both conditions have improved after tumor excision.

Keywords: Hypoglycemia; Insulin-like growth factor 2; Seborrheic keratosis; Tumor.