Long-Term Survival after Cardiac Surgery in Patients with Chronic Obstructive Pulmonary Disease

Am J Crit Care. 2016 May;25(3):266-76. doi: 10.4037/ajcc2016119.

Abstract

Background: Although many patients with chronic obstructive pulmonary disease (COPD) require a prolonged length of stay (PLOS) following coronary artery bypass grafting (CABG), the impact of PLOS on long-term survival has not been examined in this population.

Objectives: To determine the association between PLOS and long-term survival among COPD and non-COPD patients after CABG and to examine consequent policy and practice-based implications.

Methods: A retrospective cohort study of CABG patients was conducted between 2002 and 2011. Long-term survival was compared in patients with and without COPD and stratified by PLOS. Hazard ratios (HR) and 95% confidence intervals (CI) were computed using a Cox regression model.

Results: A total of 203 patients (4.2%) had PLOS after nonemergent CABG (N = 4801). PLOS was an important independent predictor of decreased long-term survival (no COPD, no PLOS: HR = 1.0; COPD, no PLOS: adjusted HR [95% CI], 1.8 [1.5-2.1]; no COPD, PLOS: 3.3 [2.5-4.4]; COPD, PLOS: 6.0 [4.4-8.2]; PTrend < .001).

Conclusions: COPD and PLOS are 2 of many factors that affect long-term mortality in postoperative CABG patients. Aggressive treatment strategies aimed at early weaning off of mechanical ventilation and prevention of reintubation among COPD patients must be considered carefully as a means to reduce length of stay after CABG. Our results also have important implications for the long-term management of these patients and strategies for containing costs over the life course of the patient.

MeSH terms

  • Aged
  • Comorbidity
  • Coronary Artery Bypass*
  • Female
  • Heart Diseases / epidemiology*
  • Heart Diseases / surgery*
  • Humans
  • Length of Stay / statistics & numerical data
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology*
  • Pulmonary Disease, Chronic Obstructive / epidemiology*
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Time Factors