Prevalence, clonal dynamics and clinical impact of TP53 mutations in patients with myelodysplastic syndrome with isolated deletion (5q) treated with lenalidomide: results from a prospective multicenter study of the german MDS study group (GMDS)

Leukemia. 2016 Sep;30(9):1956-9. doi: 10.1038/leu.2016.111. Epub 2016 May 2.
No abstract available

Publication types

  • Clinical Trial
  • Letter
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chromosome Deletion
  • Chromosomes, Human, Pair 5 / genetics
  • Female
  • Humans
  • Immunologic Factors / therapeutic use*
  • Lenalidomide
  • Male
  • Middle Aged
  • Mutation*
  • Myelodysplastic Syndromes / drug therapy*
  • Myelodysplastic Syndromes / genetics*
  • Prevalence
  • Prospective Studies
  • Thalidomide / analogs & derivatives*
  • Thalidomide / therapeutic use
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Immunologic Factors
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Thalidomide
  • Lenalidomide