Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging

J Dermatol Sci. 2016 Jul;83(1):80-3. doi: 10.1016/j.jdermsci.2016.04.004. Epub 2016 Apr 20.

Authors

Trupta Purohit¹, Tianyuan He¹, Zhaoping Qin¹, Ting Li¹, Gary J Fisher¹, Yan Yan¹, John J Voorhees¹, Taihao Quan²

Affiliations

¹ Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
² Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: thquan@umich.edu.

PMID: 27132061
DOI: 10.1016/j.jdermsci.2016.04.004

No abstract available

Publication types

Letter

MeSH terms

Collagen Type I / metabolism*
Connective Tissue / metabolism
Connective Tissue / physiology*
Fibroblasts / metabolism*
Humans
RNA Interference
RNA, Small Interfering / genetics
Signal Transduction
Skin Aging*
Smad3 Protein / genetics
Smad3 Protein / metabolism*
Transforming Growth Factor beta / metabolism

Substances

Collagen Type I
RNA, Small Interfering
SMAD3 protein, human
Smad3 Protein
Transforming Growth Factor beta