Epigenetic changes in diabetes

Rami Al-Haddad; Nabil Karnib; Rawad Abi Assaad; Yara Bilen; Nancy Emmanuel; Anthony Ghanem; Joe Younes; Victor Zibara; Joseph S Stephan; Sama F Sleiman

doi:10.1016/j.neulet.2016.04.046

Epigenetic changes in diabetes

Neurosci Lett. 2016 Jun 20:625:64-9. doi: 10.1016/j.neulet.2016.04.046. Epub 2016 Apr 27.

Authors

Affiliations

¹ Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
² School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
³ Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon. Electronic address: sama.sleiman01@lau.edu.lb.

PMID: 27130819
DOI: 10.1016/j.neulet.2016.04.046

Abstract

The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the leading causes of death. Diabetes is a genetic disease; however, the environment plays critical roles in its development and progression. Epigenetic changes often translate environmental stimuli to changes in gene expression. Changes in epigenetic marks and differential regulation of epigenetic modulators have been observed in different models of diabetes and its associated complications. In this minireview, we will focus DNA methylation, Histone acetylation and methylation and their roles in the pathogenesis of diabetes.

Keywords: DNA methylation; Diabetes; Epigenetics; HDACs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA Methylation
Diabetes Mellitus / genetics*
Epigenesis, Genetic*
Gene Expression Regulation
Histone Code
Humans
RNA, Untranslated / genetics

Substances

RNA, Untranslated