Misclassification of Antiretroviral Treatment Failure Using WHO 2006 and 2010/2013 Immunologic Criteria in HIV-Infected Children and Adolescents in Western Kenya

Elizabeth M Dufort; Allison K DeLong; Marita Mann; Winstone M Nyandiko; Samuel O Ayaya; Joseph W Hogan; Rami Kantor

doi:10.1093/jpids/piw018

Misclassification of Antiretroviral Treatment Failure Using WHO 2006 and 2010/2013 Immunologic Criteria in HIV-Infected Children and Adolescents in Western Kenya

J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):285-288. doi: 10.1093/jpids/piw018.

Authors

Elizabeth M Dufort^{1

2}, Allison K DeLong³, Marita Mann⁴, Winstone M Nyandiko⁵, Samuel O Ayaya⁵, Joseph W Hogan^{3

6}, Rami Kantor⁷

Affiliations

¹ Global Institute for Health and Human Rights, State University of New York at Albany.
² Department of Pediatrics, Albany Medical College, New York.
³ Center for Statistical Sciences, School of Public Health, Brown University.
⁴ Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle.
⁵ Department of Child Health and Pediatrics, School of Medicine, College of Health Sciences, Moi University and Moi Teaching and Referral Hospital, Eldoret, Kenya.
⁶ Department of Biostatistics, School of Public Health, Brown University, Providence, Rhode Island.
⁷ Division of Infectious Diseases, Brown University Alpert Medical School, Providence, Rhode Island.

Abstract

We evaluated treatment failure misclassification in human immunodeficiency virus-infected Kenyan children whose targeted viral loads were determined after suspected immunologic/clinical failure according to 2006 and 2010/2013 World Health Organization guidelines. The misclassification rate was 21% for the 2006 guidelines and 46% for the 2010/2013 guidelines, which supports current recommendations for routine viral load monitoring but not necessarily the proposed CD4 thresholds.

Keywords: failure; pediatric HIV; treatment.

Publication types

Observational Study

MeSH terms

Adolescent
Anti-HIV Agents / therapeutic use*
Child
Child, Preschool
Drug Resistance, Viral
Female
HIV Infections / drug therapy*
Humans
Kenya / epidemiology
Male
Retrospective Studies
Treatment Failure
Viral Load

Substances

Anti-HIV Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding