Iron-catalyzed domino indole fluorination/allenic aza-Claisen rearrangement

Benito Alcaide; Pedro Almendros; Sara Cembellín; Teresa Martínez Del Campo; Alejandro Muñoz

doi:10.1039/c6cc02012g

Iron-catalyzed domino indole fluorination/allenic aza-Claisen rearrangement

Chem Commun (Camb). 2016 May 21;52(41):6813-6. doi: 10.1039/c6cc02012g. Epub 2016 Apr 29.

Authors

Benito Alcaide¹, Pedro Almendros, Sara Cembellín, Teresa Martínez Del Campo, Alejandro Muñoz

Affiliation

¹ Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, 28040-Madrid, Spain. alcaideb@quim.ucm.es.

PMID: 27126127
DOI: 10.1039/c6cc02012g

Abstract

The synthesis of 2-allenyl-2-substituted-3,3-difluoroindolines has been accomplished, taking advantage of the reaction between N-allenyl-indoles and Selectfluor under iron catalysis.