High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses

Euro Surveill. 2016 Apr 21;21(16). doi: 10.2807/1560-7917.ES.2016.21.16.30203.

Abstract

The current Zika virus (ZIKV) epidemic in the Americas caused an increase in diagnostic requests in European countries. Here we demonstrate high specificity of the Euroimmun anti-ZIKV IgG and IgM ELISA tests using putative cross-reacting sera of European patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis C virus. This test may aid in counselling European travellers returning from regions where ZIKV is endemic.

Keywords: ELISA; European travellers; Zika virus; cross-reactivity; flavivirus; specificity.

MeSH terms

  • Autoantibodies / blood*
  • Environmental Exposure
  • Enzyme-Linked Immunosorbent Assay / methods*
  • Europe / epidemiology
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Prevalence
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Seroepidemiologic Studies
  • Zika Virus / classification*
  • Zika Virus / immunology
  • Zika Virus / isolation & purification*
  • Zika Virus Infection / blood*
  • Zika Virus Infection / epidemiology
  • Zika Virus Infection / virology*

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Immunoglobulin M