[Inhibitory Properties of Nitrogen-Containing Adamantane Derivatives with Monoterpenoid Fragments Against Tyrosyl-DNA Phosphodiesterase I]

A L Zakharenko; K U Ponomarev; E V Suslov; D V Korchagina; K P Volcho; I A Vasil'eva; N F Salakhutdinov; O I Lavrik

doi:10.1134/s1068162015060199

[Inhibitory Properties of Nitrogen-Containing Adamantane Derivatives with Monoterpenoid Fragments Against Tyrosyl-DNA Phosphodiesterase I]

Bioorg Khim. 2015 Nov-Dec;41(6):731-6. doi: 10.1134/s1068162015060199.

[Article in Russian]

Authors

A L Zakharenko, K U Ponomarev, E V Suslov, D V Korchagina, K P Volcho, I A Vasil'eva, N F Salakhutdinov, O I Lavrik

PMID: 27125028
DOI: 10.1134/s1068162015060199

Abstract

It was found that compounds combining diazaadamantane and monoterpenoid fragments are potent inhibitors of new structural type of human recombinant DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1). It was demonstrated that the inhibition efficiency depended on the length and flexibility of the aliphatic chain of the substituent.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adamantane* / chemical synthesis
Adamantane* / chemistry
Enzyme Inhibitors* / chemical synthesis
Enzyme Inhibitors* / chemistry
Humans
Monoterpenes* / chemical synthesis
Monoterpenes* / chemistry
Nitrogen / chemistry*
Phosphoric Diester Hydrolases / chemistry*

Substances

Enzyme Inhibitors
Monoterpenes
Phosphoric Diester Hydrolases
TDP1 protein, human
Nitrogen
Adamantane