Erectile Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Outcomes from a Multi-Center Study and Risk Factor Analysis in a Single Center

PLoS One. 2016 Apr 27;11(4):e0153054. doi: 10.1371/journal.pone.0153054. eCollection 2016.

Abstract

The aim of this study was to investigate the prevalence of erectile dysfunction (ED) in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and explore the influence of UPOINT domains, National Institutes of Health-CP symptom index (NIH-CPSI) and other factors on ED prevalence. This was a prospective study of consecutive patients with CP/CPPS seen at 11 tertiary hospitals during January-July 2014. ED was diagnosed as a score of<21 on the International Index of Erectile Function (IIEF-5). Patients from one center were evaluated by the UPOINT system and NIH-CPSI. Each patient was assessed using clinical examination, asocio-demographic questionnaire, the Patient Health Questionnaire (PHQ), the Pain Catastrophizing Scale (PCS), NIH-CPSI and IIEF-5.1406 patients from 11 centers (mean age, 32.18 years; range 18-60 years) were enrolled. ED was found in 638/1406 patients (45.4%), and was categorized as mild in 291(45.6%), moderate in 297(46.6%) and severe in50(7.7%). 192 patients from one center(mean age,31.3 years; range 18-57 years) were further studied.IIEF-5 score correlated negatively with NIH-CPSI(r = 0.251), PHQ (r = 0.355) and PCS (r = 0.322)scores (P<0.001).PHQ score correlated positively with NIH-CPSI (r = 0.586) and PCS(r = 0.662) scores (P<0.001).NIH-CPSI, PHQ, PCS and IIEF-5 scores did not differ significantly between class IIIA and IIIB CP/CPPS. Multivariate logistic regression showed that UPOINT psychological (P) domain and NIH-CPSI symptom severity were independent risk factors for ED in CP/CPPS. It is concluded that psychological factors and symptom severity are independent risk factors for ED in CP/CPPS.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Chronic Disease
  • Chronic Pain / complications*
  • Erectile Dysfunction / epidemiology*
  • Erectile Dysfunction / etiology*
  • Factor Analysis, Statistical
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • National Institutes of Health (U.S.)
  • Pelvic Pain / complications*
  • Prevalence
  • Prospective Studies
  • Prostatitis / complications*
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Surveys and Questionnaires
  • United States
  • Young Adult

Grants and funding

This project was supported by the National Natural Science Foundation of China (grant no. 81270696), the Natural Science Foundation of Guangdong Province (grant no. S2013040012294), Guangdong Provincial Medical Research Foundation (grant no. C2013022), Science and Technology Planning Project of Guangdong Province (grant no. 2012B031800361) and Science and Technology Planning Project of Guangzhou (grant no. 2013J4500010).