Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

Patrick van Rijn; Romana Schirhagl

doi:10.1002/adhm.201501000

Viruses, Artificial Viruses and Virus-Based Structures for Biomedical Applications

Adv Healthc Mater. 2016 Jun;5(12):1386-400. doi: 10.1002/adhm.201501000. Epub 2016 Apr 27.

Authors

Patrick van Rijn^{1

2}, Romana Schirhagl¹

Affiliations

¹ University of Groningen, University Medical Center Groningen, Biomedical Engineering-FB40, W.J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, Antonius Deusinglaan 1, 9713, AW, Groningen, Netherlands.
² Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, Netherlands.

PMID: 27119823
DOI: 10.1002/adhm.201501000

Abstract

Nanobiomaterials such as virus particles and artificial virus particles offer tremendous opportunities to develop new biomedical applications such as drug- or gene-delivery, imaging and sensing but also improve understanding of biological mechanisms. Recent advances within the field of virus-based systems give insights in how to mimic viral structures and virus assembly processes as well as understanding biodistribution, cell/tissue targeting, controlled and triggered disassembly or release and circulation times. All these factors are of high importance for virus-based functional systems. This review illustrates advances in mimicking and enhancing or controlling these aspects to a high degree toward delivery and imaging applications.

Keywords: biomedical applications; delivery; imaging; nanobiomaterials; virus particles.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomedical Research
Biomimetic Materials*
Diagnostic Imaging / methods*
Drug Delivery Systems / methods*
Gene Transfer Techniques*
Humans
Viruses*