Abstract
Hydrogen sulfide (H(2)S) is a gasomediator synthesized from L- and D-cysteine in various tissues. It is involved in a number of physiological and pathological processes. H(2)S exhibits antiatherosclerotic, vasodilator, and proangiogenic properties, and protects the kidney and heart from damage following ischemia/reperfusion injury. H(2)S donors may be natural or synthetic, and may be used for the safe treatment of a wide range of diseases. This review article summarizes the current state of knowledge of the therapeutic function of H(2)S.
Keywords:
Gasotransmitter; H(2)S donor; Hydrogen sulfide.
© 2016 Elsevier Inc. All rights reserved.
MeSH terms
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Angiogenesis Inducing Agents / metabolism
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Angiogenesis Inducing Agents / therapeutic use*
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Cardiovascular Agents / metabolism
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Cardiovascular Agents / therapeutic use*
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Cysteine / metabolism
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Diclofenac / analogs & derivatives
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Diclofenac / metabolism
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Diclofenac / therapeutic use
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Disulfides / metabolism
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Disulfides / therapeutic use
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Heart / drug effects
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Heart / physiopathology
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Humans
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Hydrogen Sulfide / metabolism
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Hydrogen Sulfide / therapeutic use*
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Kidney / drug effects
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Kidney / metabolism
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Kidney / physiopathology
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Levodopa / analogs & derivatives
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Levodopa / metabolism
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Levodopa / therapeutic use
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Prostaglandins F, Synthetic / metabolism
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Prostaglandins F, Synthetic / therapeutic use
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Reperfusion Injury / drug therapy*
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Reperfusion Injury / metabolism
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Reperfusion Injury / physiopathology
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Sulfides / metabolism
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Sulfides / therapeutic use
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Thioctic Acid / analogs & derivatives
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Thioctic Acid / metabolism
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Thioctic Acid / therapeutic use
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Thiones / metabolism
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Thiones / therapeutic use
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Vasodilator Agents / metabolism
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Vasodilator Agents / therapeutic use*
Substances
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2-((2,6-dichlorophenyl)amino) benzeneacetic acid 4-(3-thioxo-3H-1,2-dithiol-5-yl) phenyl ester
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ACS 84
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ACS67 compound
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Angiogenesis Inducing Agents
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Cardiovascular Agents
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Disulfides
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Prostaglandins F, Synthetic
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Sulfides
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Thiones
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Vasodilator Agents
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Diclofenac
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Levodopa
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Thioctic Acid
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sodium bisulfide
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Cysteine
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sodium sulfide
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Hydrogen Sulfide