Data supporting the role of Fyn in initiating myelination in the peripheral nervous system

Yuki Miyamoto; Moe Tamano; Tomohiro Torii; Kazuko Kawahara; Kazuaki Nakamura; Akito Tanoue; Shuji Takada; Junji Yamauchi

doi:10.1016/j.dib.2016.03.096

Data supporting the role of Fyn in initiating myelination in the peripheral nervous system

Data Brief. 2016 Apr 1:7:1098-105. doi: 10.1016/j.dib.2016.03.096. eCollection 2016 Jun.

Authors

Yuki Miyamoto¹, Moe Tamano², Tomohiro Torii¹, Kazuko Kawahara¹, Kazuaki Nakamura¹, Akito Tanoue¹, Shuji Takada³, Junji Yamauchi⁴

Affiliations

¹ Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
² Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
³ Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, Japan.
⁴ Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, Japan.

Abstract

Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) "Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2015 [1])". Herein we provide the data regarding myelination-related protein markers and myelin ultrastructure in transgenic mice.

Keywords: Fyn; Myelin marker protein; Myelination; Peripheral nervous system; Signaling.