Chemical constituents of Solanum coagulans and their antimicrobial activities

Xu-Jie Qin; Paul-Keilah Lunga; Yun-Li Zhao; Ya-Ping Liu; Xiao-Dong Luo

doi:10.1016/S1875-5364(16)30033-4

Chemical constituents of Solanum coagulans and their antimicrobial activities

Chin J Nat Med. 2016 Apr;14(4):308-312. doi: 10.1016/S1875-5364(16)30033-4.

Authors

Xu-Jie Qin¹, Paul-Keilah Lunga², Yun-Li Zhao³, Ya-Ping Liu⁴, Xiao-Dong Luo⁵

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China; University of Chinese Academy of Science, Beijing 100049, China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China; Department of Biochemistry, Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, Yaoundé P. O. Box 812, Cameroon.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China.
⁴ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China. Electronic address: liuyaping@mail.kib.ac.cn.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China. Electronic address: xdluo@mail.kib.ac.cn.

PMID: 27114320
DOI: 10.1016/S1875-5364(16)30033-4

Abstract

The present study aimed at determining the chemical constituents of Solanum coagulans and their antimicrobial activities. The compounds were isolated by various chromatographic techniques and their structures were elucidated on the basis of extensive spectroscopic analysis, chemical methods, and comparison with reported spectroscopic data. One new phenolic glycoside, methyl salicylate 2-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1), together with 12 known compounds (2-13), were isolated from the aerial parts of Solanum coagulans. Compound 1 was a new phenolic glycoside, and 2-6 were isolated from Solanum genus for the first time. The antimicrobial activities of the isolated compounds were also evaluated. Compound 7 showed remarkable antifungal activity against T. mentagrophytes, M. gypseum and E. floccosum with MIC values being 3.13, 1.56 and 3.13 μg·mL(-1), respectively.

Keywords: Solanum coagulans; antimicrobial activity; chemical constituents.

MeSH terms

Anti-Infective Agents / chemistry*
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology*
Bacteria / drug effects
Drugs, Chinese Herbal / chemistry*
Drugs, Chinese Herbal / isolation & purification
Drugs, Chinese Herbal / pharmacology*
Fungi / drug effects
Glycosides / chemistry*
Glycosides / isolation & purification
Glycosides / pharmacology*
Molecular Structure
Solanum / chemistry*

Substances

Anti-Infective Agents
Drugs, Chinese Herbal
Glycosides