Widespread Dissemination of Carbapenem-Resistant Escherichia coli Sequence Type 167 Strains Harboring blaNDM-5 in Clinical Settings in China

Yonglu Huang; Xiaonan Yu; Miaomiao Xie; Xuan Wang; Kang Liao; Wencheng Xue; Edward Wai-Chi Chan; Rong Zhang; Sheng Chen

doi:10.1128/AAC.00859-16

Widespread Dissemination of Carbapenem-Resistant Escherichia coli Sequence Type 167 Strains Harboring blaNDM-5 in Clinical Settings in China

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4364-8. doi: 10.1128/AAC.00859-16. Print 2016 Jul.

Authors

Yonglu Huang¹, Xiaonan Yu², Miaomiao Xie³, Xuan Wang¹, Kang Liao⁴, Wencheng Xue², Edward Wai-Chi Chan⁵, Rong Zhang⁶, Sheng Chen⁷

Affiliations

¹ Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
² Department of Transfusion, General Hospital of Shenyang Military Area Command, Shenyang, China.
³ Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People's Republic of China.
⁴ First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
⁵ State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
⁶ Second Affiliated Hospital of Zhejiang University, Hangzhou, China brigitte_zx@163.com sheng.chen@polyu.edu.hk.
⁷ Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People's Republic of China State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong brigitte_zx@163.com sheng.chen@polyu.edu.hk.

Abstract

This study reports the increasing prevalence of clinical Escherichia coli of sequence type 167 (ST167) carrying both blaNDM-1 and blaNDM-5 on the conjugative IncX3 plasmid in various parts of China. Close surveillance is needed to monitor the future dissemination of ST167 strains that harbor blaNDM-5 or other blaNDM-like genes.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Carbapenems / pharmacology*
China
Escherichia coli / drug effects*
Escherichia coli / enzymology*
Escherichia coli / genetics
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism
Microbial Sensitivity Tests
beta-Lactamases

Substances

Anti-Bacterial Agents
Carbapenems
Escherichia coli Proteins
beta-Lactamases

Grants and funding

This work was funded by the Chinese National Key Basic Research and Development (973) Program (2013CB127200).