Bioengineering Lungs for Transplantation

Sarah E Gilpin; Jonathan M Charest; Xi Ren; Harald C Ott

doi:10.1016/j.thorsurg.2015.12.004

Bioengineering Lungs for Transplantation

Thorac Surg Clin. 2016 May;26(2):163-71. doi: 10.1016/j.thorsurg.2015.12.004.

Authors

Sarah E Gilpin¹, Jonathan M Charest², Xi Ren¹, Harald C Ott³

Affiliations

¹ Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.
² Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
³ Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: hott@mgh.harvard.edu.

PMID: 27112255
DOI: 10.1016/j.thorsurg.2015.12.004

Abstract

Whole lung extracellular matrix scaffolds can be created by perfusion of cadaveric organs with decellularizing detergents, providing a platform for organ regeneration. Lung epithelial engineering must address both the proximal airway cells that function to metabolize toxins and aid mucociliary clearance and the distal pneumocytes that facilitate gas exchange. Engineered pulmonary vasculature must support in vivo blood perfusion with low resistance and intact barrier function and be antithrombotic. Repopulating the native lung matrix with sufficient cell numbers in appropriate anatomic locations is required to enable organ function.

Keywords: Bioartificial lung; Endothelium; Epithelium; Lung regeneration; Organ culture; Tissue engineering.

Publication types

Review

MeSH terms

Bioengineering / methods*
Humans
Lung Transplantation / methods*
Tissue Engineering / methods*
Tissue Scaffolds*