Vegetation plays an important role in regulating the terrestrial carbon balance and the climate system, and also overwhelmingly dominates the provisioning of ecosystem services. Therefore, it has significance to monitor the growth of vegetation. Based on AVHRR GIMMS NDVI and MODIS NDVI datasets, we analyzed the spatiotemporal patterns of change in NDVI and their linkage with climate change and human activity from 1982 to 2012 in the typical arid region, Xinjiang of northwestern China, at pixel and regional scales. At regional scale, although a statistically significant positive trend of growing season NDVI with a rate of 4.09 x 10⁻⁴· a⁻¹ was found during 1982-2012, there were two distinct periods with opposite trends in growing season NDVI before and after 1998, respectively. NDVI in growing season first significantly increased with a rate of 10 x 10⁻⁴· a⁻¹ from 1982 to 1998, and then decreased with a rate of -3 x 10⁻⁴· a⁻¹ from 1998 to 2012. The change in trend of NDVI from increase to decrease mainly occurred in summer, followed by autumn, and the reversal wasn't observed in spring. At pixel scale, the NDVI in farmland significantly increased; the NDVI changes in the growing season and all seasons showed polarization: Areas with significant change mostly increased in size as the NDVI record grown in length. The rate of increase in size of areas with significantly decreasing NDVI was larger than that with significantly increasing NDVI, which led to the NDVI increase obviously slowing down or stopping at regional scale. The vegetation growth in the study area was regulated by both climate change and human activity. Temperature was the most important driving factor in spring and autumn, whereas precipitation in summer. Extensive use of fertilizers and increased farmland irrigated area promoted the vegetation growth. However, the rapid increase in the proportion of cotton cultivation and use of drip irrigation might reduce spring NDVI in the part of farmlands, and the increase in stocking levels of livestock might lead to a decrease in NDVI in some grasslands.