Enhancer, epigenetics, and human disease

Zhuojuan Luo; Chengqi Lin

doi:10.1016/j.gde.2016.03.012

Enhancer, epigenetics, and human disease

Curr Opin Genet Dev. 2016 Feb:36:27-33. doi: 10.1016/j.gde.2016.03.012. Epub 2016 Apr 22.

Authors

Zhuojuan Luo¹, Chengqi Lin²

Affiliations

¹ Transcriptional Control in Development and Disease Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore.
² Transcriptional Control in Development and Disease Laboratory, A*STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Institute of Life Sciences, the Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China. Electronic address: cqlin@imcb.a-star.edu.sg.

PMID: 27107478
DOI: 10.1016/j.gde.2016.03.012

Abstract

Enhancers encode a huge body of information to determine the precise tissue specific gene expression pattern during normal development. Nowadays, enhancers are also considered as key players in directing disease transcriptional program during pathogenesis. New genomic technologies allow the identification, functional characterization and manipulation of enhancers. The advances in the transcriptional enhancer field hold great promise in linking developmental or disease phenotypes to genetic variants and promoting precision medicine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Enhancer Elements, Genetic*
Epigenesis, Genetic
Gene Expression Regulation, Developmental
Genetic Diseases, Inborn*
Genomics*
Humans
Organ Specificity
Precision Medicine
Transcription, Genetic*