Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes

Kamonrat Phopin; Nujarin Sinthupoom; Lertyot Treeratanapiboon; Sarun Kunwittaya; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul

doi:10.17179/excli2016-101

Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes

EXCLI J. 2016 Feb 18:15:144-52. doi: 10.17179/excli2016-101. eCollection 2016.

Authors

Kamonrat Phopin¹, Nujarin Sinthupoom², Lertyot Treeratanapiboon³, Sarun Kunwittaya², Supaluk Prachayasittikul⁴, Somsak Ruchirawat⁵, Virapong Prachayasittikul²

Affiliations

¹ Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
² Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
³ Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
⁴ Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
⁵ Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, and Program in Chemical Biology, Chulabhorn Graduate Institute, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology, Commission on Higher Education (CHE), Ministry of Education, Thailand.

Abstract

8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

Keywords: aminoquinoline; antimalarial; antimicrobial; metal complexes; uracils.