Minimax probability machine (MPM) is an interesting discriminative classifier based on generative prior knowledge. It can directly estimate the probabilistic accuracy bound by minimizing the maximum probability of misclassification. The structural information of data is an effective way to represent prior knowledge, and has been found to be vital for designing classifiers in real-world problems. However, MPM only considers the prior probability distribution of each class with a given mean and covariance matrix, which does not efficiently exploit the structural information of data. In this paper, we use two finite mixture models to capture the structural information of the data from binary classification. For each subdistribution in a finite mixture model, only its mean and covariance matrix are assumed to be known. Based on the finite mixture models, we propose a structural MPM (SMPM). SMPM can be solved effectively by a sequence of the second-order cone programming problems. Moreover, we extend a linear model of SMPM to a nonlinear model by exploiting kernelization techniques. We also show that the SMPM can be interpreted as a large margin classifier and can be transformed to support vector machine and maxi-min margin machine under certain special conditions. Experimental results on both synthetic and real-world data sets demonstrate the effectiveness of SMPM.