Discovery of a novel target for renal cell carcinoma: transglutaminase 2

Cell Death Dis. 2016 Apr 21;7(4):e2200. doi: 10.1038/cddis.2016.99.

Authors

J H Kang¹, S-H Lee¹, S-Y Kim¹

Affiliation

¹ Cancer Cell and Molecular Biology Branch, Division of Cancer Biology, Research Institute, National Cancer Center, Goyang, Gyeonggi-do, Korea.

No abstract available

Publication types

News
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Carcinoma, Renal Cell / drug therapy
Carcinoma, Renal Cell / metabolism
Carcinoma, Renal Cell / pathology*
Enzyme Inhibitors / pharmacology
Enzyme Inhibitors / therapeutic use
GTP-Binding Proteins / antagonists & inhibitors
GTP-Binding Proteins / metabolism*
Humans
Kidney Neoplasms / drug therapy
Kidney Neoplasms / metabolism
Kidney Neoplasms / pathology*
Protein Binding
Protein Glutamine gamma Glutamyltransferase 2
Pyrazines / pharmacology
Pyrazines / therapeutic use
Transglutaminases / antagonists & inhibitors
Transglutaminases / metabolism*
Tumor Suppressor Protein p53 / chemistry
Tumor Suppressor Protein p53 / metabolism

Substances

3-(phenylethynyl)-2-(2-(pyridin-2-yl)ethoxy)pyrido(3,2-b)pyrazine
Enzyme Inhibitors
Pyrazines
Tumor Suppressor Protein p53
Protein Glutamine gamma Glutamyltransferase 2
Transglutaminases
GTP-Binding Proteins