Abstract
We investigated the molecular epidemiology and microbiological characteristics of 51 Escherichia coli isolates causing hospital-acquired pneumonia (HAP) in eight Asian areas. Sequence type 131 (ST131) was the most prevalent among E. coli isolates causing HAP, especially in South Korea, Thailand, and the Philippines. The current study showed that CTX-M-15-producing E. coli ST131 has emerged in and disseminated among patients with HAP in Asia. Our data suggest that this pandemic clone poses an important public health threat even in nosocomial infections.
Keywords:
ESBL; Escherichia coli; ST131; pneumonia.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Asia, Southeastern / epidemiology
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Asia, Western / epidemiology
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Cross Infection / epidemiology*
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Cross Infection / microbiology
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Cross Infection / transmission
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DNA, Bacterial / genetics
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Escherichia coli / drug effects
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Escherichia coli / genetics
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Escherichia coli / growth & development
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Escherichia coli / isolation & purification*
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Escherichia coli Infections / epidemiology*
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Escherichia coli Infections / microbiology
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Escherichia coli Infections / transmission
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Hospitals
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Humans
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Multilocus Sequence Typing
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Pneumonia, Bacterial / epidemiology*
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Pneumonia, Bacterial / microbiology
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Pneumonia, Bacterial / transmission
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Prevalence
Substances
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Anti-Bacterial Agents
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DNA, Bacterial