Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds

Tânia S Morais; Andreia Valente; Ana Isabel Tomaz; Fernanda Marques; Maria Helena Garcia

doi:10.4155/fmc.16.7

Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds

Future Med Chem. 2016 Apr;8(5):527-44. doi: 10.4155/fmc.16.7. Epub 2016 Apr 20.

Authors

Tânia S Morais^{1

2}, Andreia Valente¹, Ana Isabel Tomaz¹, Fernanda Marques³, Maria Helena Garcia¹

Affiliations

¹ Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
² Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.
³ Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, E.N.10, 2695-066 Bobadela LRS, Portugal.

PMID: 27096164
DOI: 10.4155/fmc.16.7

Abstract

Research on the field of metal complexes for the treatment of cancer diseases has attracted increasing interest due to the urgency in finding more efficient and selective treatments. Owing to their wide structural diversity, organometallic complexes appear as potential alternatives to the design of new anticancer candidates. Herein, we review recent progress in our work toward the development of new drugs based on Ru(II)- and Fe(II)-cyclopentadienyl scaffolds. Their design and chemical properties are reviewed and correlated with their biological effects, in particular the key role that coligands play in the overall behavior of the complex.

Keywords: anticancer; cellular uptake; cyclopentadienyl; cytotoxicity; iron(II); molecular targets; organometallic; ruthenium(II).

Publication types

Review

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use
Cell Line, Tumor
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Coordination Complexes / therapeutic use
Cyclopentanes / chemistry
Dimethyl Sulfoxide / analogs & derivatives
Dimethyl Sulfoxide / chemistry
Dimethyl Sulfoxide / pharmacology
Dimethyl Sulfoxide / therapeutic use
Drug Discovery
Ferrous Compounds / chemistry
Ferrous Compounds / pharmacology*
Ferrous Compounds / therapeutic use
Humans
Indazoles / chemistry
Indazoles / pharmacology
Indazoles / therapeutic use
Molecular Targeted Therapy
Neoplasms / drug therapy*
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology
Organometallic Compounds / therapeutic use
Protein Binding
Ruthenium / chemistry
Ruthenium / pharmacology*
Ruthenium / therapeutic use
Ruthenium Compounds

Substances

Antineoplastic Agents
Coordination Complexes
Cyclopentanes
Ferrous Compounds
Indazoles
Organometallic Compounds
Ruthenium Compounds
imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)
indazolium trans-(tetrachlorobis(1H-indazole)ruthenate (III))
Ruthenium
Dimethyl Sulfoxide