Abstract
Two new steroidal glycosides ponasteroside C (1) and ponasteroside D (2) were isolated from the aerial parts of Lepidogrammitis drymoglossoides. Their structures were elucidated by various spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cell lines, and compounds 1 and 2 showed mild activity against all the test cell lines.
Keywords:
Lepidogrammitis drymoglossoides; Polypodiaceae; cytotoic activity; steroidal glycosides.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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HeLa Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phytosterols / chemistry
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Phytosterols / isolation & purification*
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Phytosterols / pharmacology
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Plant Components, Aerial / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Glycosides
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Phytosterols
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ponasteroside C
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ponasteroside D