Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species

Chem Soc Rev. 2016 May 21;45(10):2976-3016. doi: 10.1039/c6cs00192k. Epub 2016 Apr 19.

Abstract

Reactive oxygen (ROS) and nitrogen (RNS) species cause oxidative and nitrosative stresses, respectively. These stresses are implicated not only in diverse physiological processes but also in various pathological processes, including cancer and neurodegenerative disorders. In addition, some ROS and RNS in the environment are pollutants that threaten human health. As a consequence of these effects, sensitive methods, which can be employed to selectively monitor ROS and RNS in live cells, tissues and organisms as well as in environmental samples, are needed so that their biological roles can be understood and their concentrations in environmental samples can be determined. In this review, fluorescent, luminescent and colorimetric ROS and RNS probes, which have been developed since 2011, are comprehensively discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Colorimetry*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Luminescence
  • Luminescent Agents / chemistry*
  • Microscopy, Fluorescence
  • Nanoparticles / chemistry
  • Nitrogen / chemistry
  • Optical Imaging / methods
  • Oxygen / chemistry
  • Reactive Nitrogen Species / analysis*
  • Reactive Oxygen Species / analysis*

Substances

  • Fluorescent Dyes
  • Luminescent Agents
  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Nitrogen
  • Oxygen