RNase 7 in Cutaneous Defense

Int J Mol Sci. 2016 Apr 14;17(4):560. doi: 10.3390/ijms17040560.

Abstract

RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases.

Keywords: RNase 7; antimicrobial peptides (AMPs); cutaneous defense.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / analysis
  • Anti-Infective Agents / immunology*
  • Bacteria / immunology
  • Bacterial Infections / genetics
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Bacterial Physiological Phenomena
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate
  • Ribonucleases / analysis
  • Ribonucleases / genetics
  • Ribonucleases / immunology*
  • Skin / immunology
  • Skin / microbiology*
  • Skin / virology*
  • Skin Diseases / genetics
  • Skin Diseases / immunology*
  • Skin Diseases / microbiology
  • Virus Diseases / genetics
  • Virus Diseases / immunology*
  • Virus Diseases / virology
  • Virus Physiological Phenomena
  • Viruses / immunology

Substances

  • Anti-Infective Agents
  • Ribonucleases
  • Ribonuclease 7