Abstract
RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases.
Keywords:
RNase 7; antimicrobial peptides (AMPs); cutaneous defense.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Infective Agents / analysis
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Anti-Infective Agents / immunology*
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Bacteria / immunology
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Bacterial Infections / genetics
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Bacterial Infections / immunology*
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Bacterial Infections / microbiology
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Bacterial Physiological Phenomena
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Gene Expression Regulation
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Host-Pathogen Interactions
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Humans
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Immunity, Innate
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Ribonucleases / analysis
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Ribonucleases / genetics
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Ribonucleases / immunology*
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Skin / immunology
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Skin / microbiology*
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Skin / virology*
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Skin Diseases / genetics
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Skin Diseases / immunology*
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Skin Diseases / microbiology
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Virus Diseases / genetics
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Virus Diseases / immunology*
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Virus Diseases / virology
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Virus Physiological Phenomena
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Viruses / immunology
Substances
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Anti-Infective Agents
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Ribonucleases
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Ribonuclease 7