Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

Molecules. 2016 Apr 14;21(4):492. doi: 10.3390/molecules21040492.

Abstract

This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed.

Keywords: bioactive molecules; cycloaddition; cyclocondensation; microwave irradiation; multicomponent reactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Combinatorial Chemistry Techniques
  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / chemistry
  • Microwaves
  • Organic Chemicals / chemical synthesis*
  • Organic Chemicals / chemistry
  • Stereoisomerism

Substances

  • Heterocyclic Compounds
  • Organic Chemicals