Abstract
The minimum requirement for mitochondrial apoptosis has been controversial ever since the discovery of BCL-2 as a cell death regulator. In this issue ofGenes&Development, O'Neill and colleagues (pp. 973-988) end a long-standing debate by creating a cellular system free of BCL-2 family proteins, thereby identifying the outer mitochondrial membrane rather than BH3-only proteins as the only requirement for BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP).
Keywords:
BH3-only; Bax/Bak activation; anti-apoptotic Bcl-2 proteins; outer mitochondrial membrane.
© 2016 Sáez and Villunger; Published by Cold Spring Harbor Laboratory Press.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / genetics
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Apoptosis Regulatory Proteins / genetics
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Apoptosis Regulatory Proteins / metabolism
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CRISPR-Cas Systems
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Humans
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism*
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Mitochondria / genetics
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Mitochondria / metabolism
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Mitochondrial Membranes / metabolism*
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Models, Biological
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Permeability
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Proto-Oncogene Proteins c-bcl-2 / metabolism*
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bcl-2 Homologous Antagonist-Killer Protein / genetics*
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bcl-2 Homologous Antagonist-Killer Protein / metabolism
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bcl-2-Associated X Protein / genetics*
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bcl-2-Associated X Protein / metabolism
Substances
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Apoptosis Regulatory Proteins
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Membrane Proteins
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Proto-Oncogene Proteins c-bcl-2
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bcl-2 Homologous Antagonist-Killer Protein
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bcl-2-Associated X Protein