Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease

Psychiatry Res. 2016 May 30:239:342-5. doi: 10.1016/j.psychres.2016.03.045. Epub 2016 Mar 31.

Abstract

The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined. Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.

Keywords: Antimicrobial peptides; Cerebrospinal fluid; Copy number polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / blood
  • Alzheimer Disease / cerebrospinal fluid
  • Alzheimer Disease / genetics*
  • Case-Control Studies
  • Female
  • Gene Dosage
  • Humans
  • Male
  • alpha-Defensins / blood
  • alpha-Defensins / cerebrospinal fluid
  • alpha-Defensins / genetics*
  • beta-Defensins / blood
  • beta-Defensins / cerebrospinal fluid
  • beta-Defensins / genetics*

Substances

  • DEFB4A protein, human
  • alpha-Defensins
  • beta-Defensins
  • human neutrophil peptide 1