FGF23 as a calciotropic hormone

María E Rodríguez-Ortiz; Mariano Rodríguez

doi:10.12688/f1000research.7189.1

FGF23 as a calciotropic hormone

F1000Res. 2015 Dec 18:4:F1000 Faculty Rev-1472. doi: 10.12688/f1000research.7189.1. eCollection 2015.

Authors

María E Rodríguez-Ortiz¹, Mariano Rodríguez²

Affiliations

¹ Laboratory of Nephrology, IIS-Fundación Jiménez Díaz, Madrid, Spain, 28040, Spain.
² Nephrology Service and Maimónides Institute for Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Avda. Menéndez Pidal, S/N, 14004 Córdoba, Spain.

Abstract

Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol - 1,25(OH) 2D 3 - and induces phosphaturia. The consequences of a reduction in 1,25(OH) 2D 3 involve changes in calcium homeostasis. There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently, several studies have demonstrated that calcium also modulates FGF23 production. In a situation of calcium deficiency, the presence of 1,25(OH) 2D 3 is necessary to optimize intestinal absorption of calcium, and FGF23 is decreased to avoid a reduction in 1,25(OH) 2D 3 levels.

Keywords: FGF receptor; FGF23; calcium.

Publication types

Review

Grants and funding

M. Rodríguez has received research grants from Amgen and Fresenius, and lecture fees from Abbvie, Amgen, Fresenius, and Shire.