Enantioselective Organocatalytic Cyclopropanation of Enals Using Benzyl Chlorides

J Org Chem. 2016 May 6;81(9):3488-500. doi: 10.1021/acs.joc.5b02801. Epub 2016 Apr 22.

Abstract

Herein, we describe the first enantioselective cyclopropanation of enals using benzyl chlorides as bifunctional (nucleophilic and electrophilic) reagents. The reaction is simply catalyzed by chiral secondary amines to afford the formyl cyclopropane derivatives in good yields with moderate to excellent stereoselectivities.

Publication types

  • Research Support, Non-U.S. Gov't