We calculate the efficiency at the unified trade-off optimization criterion (the so-called maximum Ω criterion) representing a compromise between the useful energy and the lost energy of heat engines operating between two reservoirs at different temperatures and chemical potentials, and demonstrate that the linear coefficient 3/4 and quadratic coefficient 1/32 of the efficiency at maximum Ω are universal for heat engines under strong coupling and symmetry conditions. It is further proved that the conclusions obtained here also apply to the ecological optimization criterion.