Drugs for Chronic Hepatitis C Infection: Clinical Review [Internet]

George Wells; Shannon Kelly; Bechara Farah; Sumeet Singh; Li Chen; Shuching Hsieh; David Kaunelis

Drugs for Chronic Hepatitis C Infection: Clinical Review [Internet]

Review

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Jan.

CADTH Therapeutic Reviews.

Authors

George Wells¹, Shannon Kelly¹, Bechara Farah², Sumeet Singh², Li Chen¹, Shuching Hsieh¹, David Kaunelis²

Affiliations

¹ University of Ottawa Heart Institute (UOHI), University of Ottawa, Ontario
² CADTH, Ottawa, Ontario

PMID: 27077176
Bookshelf ID: NBK350686

Excerpt

The objective of this systematic review was to assess the comparative efficacy and safety of currently available and emerging regimens for the treatment of chronic hepatitis C (CHC) infection (genotypes 1 to 6).

Sections

ABBREVIATIONS AND GLOSSARY
TREATMENT REGIMEN NOMENCLATURE
EXECUTIVE SUMMARY
CONTEXT AND POLICY ISSUES
METHODS
RESULTS: SYSTEMATIC REVIEW
RESULTS: EFFICACY — SUSTAINED VIROLOGIC RESPONSE AT 12 WEEKS
RESULTS: HARMS — ADVERSE EVENTS
DISCUSSION
CONCLUSIONS AND IMPLICATIONS FOR DECISION-MAKING
REFERENCES
APPENDIX 1. PATIENT INPUT INFORMATION
APPENDIX 2. REGIMENS ELIGIBLE FOR INCLUSION BY GENOTYPE
APPENDIX 3. ELECTRONIC SEARCH STRATEGY
APPENDIX 4. INCLUDED STUDY LIST (N = 67 STUDIES REPORTED IN N = 63 PUBLICATIONS)
APPENDIX 5. EXCLUDED STUDY LIST AND STUDY ARMS
APPENDIX 6. DETAILED STUDY CHARACTERISTICS
APPENDIX 7. DETAILED PATIENT CHARACTERISTICS
APPENDIX 8. DETAILED DOSAGE REGIMENS
APPENDIX 9. DETAILED CRITICAL APPRAISAL OF INCLUDED STUDIES
APPENDIX 10. DETAILED NETWORK META-ANALYSIS RESULTS AND EVALUATION OF CONSISTENCY
APPENDIX 11. DETAILED NETWORK META-ANALYSIS RESULTS AND CONSISTENCY PLOTS — HARMS (ALL GENOTYPES)
APPENDIX 12. RESULTS FROM SUBGROUP AND SENSITIVITY ANALYSES
APPENDIX 13. DETAILED RESULTS FOR OTHER OUTCOMES
APPENDIX 14. SUMMARY OF INCLUDED STUDIES BY OUTCOMES

Publication types

Review