Random walk of passive tracers among randomly moving obstacles

Theor Biol Med Model. 2016 Apr 14:13:13. doi: 10.1186/s12976-016-0038-1.

Abstract

Background: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly walking biomolecule is also subject to a long-range force field driving it to its target.

Method: By means of the Continuous Time Random Walk (CTRW) technique the topic of random walk in random environment is here considered in the case of a passively diffusing particle among randomly moving and interacting obstacles.

Results: The relevant physical quantity which is worked out is the diffusion coefficient of the passive tracer which is computed as a function of the average inter-obstacles distance.

Conclusions: The results reported here suggest that if a biomolecule, let us call it a test molecule, moves towards its target in the presence of other independently interacting molecules, its motion can be considerably slowed down.

Keywords: Diffusion of biomolecules; Probability theory; Stochastic models in biological physics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Cytoplasm / metabolism
  • Diffusion
  • Macromolecular Substances
  • Models, Biological*
  • Models, Statistical
  • Motion*
  • Probability
  • Stochastic Processes

Substances

  • Macromolecular Substances