Background: The study aimed at in vivo pharmacokinetic evaluation of carvedilol loaded nanocapsules (CLN) followed by in silico predictions and establishment of IVIVC.
Method: LC/MS-MS method was developed and validated to estimate the pharmacokinetic profile of CLN. The in silico and IVIVC were established using GastroPlus.
Results: The CLN demonstrated 221.09% increase in bioavailability of carvedilol over aqueous suspension. The simulation of plasma concentration profile of CLN exhibited a sensible level of superimposition. The regional absorption of the CLN showed maximum absorption from duodenum and jejunum. The Wagner-Nelson method was found to be most suitable deconvolution method for establishing the IVIVC of CLN.
Conclusion: The study demonstrated CLN as efficient delivery system to ferry carvedilol with improved bioavailability.
Keywords: GastroPlus™; IVIVC; LC/MS-MS; Wagner–Nelson Method; carvedilol nanocapsules; in silico studies.