Hydrogen sulphide in cardiovascular system: A cascade from interaction between sulphur atoms and signalling molecules

Ming-Jie Wang; Wen-Jie Cai; Yi-Chun Zhu

doi:10.1016/j.lfs.2016.03.057

Hydrogen sulphide in cardiovascular system: A cascade from interaction between sulphur atoms and signalling molecules

Life Sci. 2016 May 15:153:188-97. doi: 10.1016/j.lfs.2016.03.057. Epub 2016 Apr 9.

Authors

Ming-Jie Wang¹, Wen-Jie Cai², Yi-Chun Zhu³

Affiliations

¹ Research Center on Aging and Medicine, Fudan University, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China.
² Department of Basic Medicine, College of Medical Instruments and Foodstuff, University of Shanghai for Science and Technology, Shanghai, China.
³ Research Center on Aging and Medicine, Fudan University, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: yczhu@shmu.edu.cn.

PMID: 27071836
DOI: 10.1016/j.lfs.2016.03.057

Abstract

As a gasotransmitter, hydrogen sulphide exerts its extensive physiological and pathophysiological effects in mammals. The interaction between sulphur atoms and signalling molecules forms a cascade that modulates cellular functions and homeostasis. In this review, we focus on the signalling mechanism underlying the effect of hydrogen sulphide in the cardiovascular system and metabolism as well as the biological relevance to human diseases.

Keywords: Atomic biology; Cardiovascular system; Hydrogen sulphide; Metabolism; Signal transduction.

Publication types

Review

MeSH terms

Cardiovascular System / metabolism*
Hydrogen Sulfide / metabolism*
Signal Transduction*
Sulfur / metabolism*

Substances

Sulfur
Hydrogen Sulfide