Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

Mehdi Mirsaeidi; Sanaz Gidfar; Ann Vu; Dean Schraufnagel

doi:10.1186/s12967-016-0843-7

Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

J Transl Med. 2016 Apr 12:14:89. doi: 10.1186/s12967-016-0843-7.

Authors

Mehdi Mirsaeidi¹, Sanaz Gidfar², Ann Vu³, Dean Schraufnagel⁴

Affiliations

¹ Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, Miller School of Medicine, 1600 NW 10th Ave # 7060A, Miami, FL, 33136, USA. msm249@med.miami.edu.
² Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA.
³ Department of Medicine, University of Miami, Miami, FL, USA.
⁴ Division of Pulmonary and Critical Care, University of Illinois at Chicago, Chicago, IL, USA.

Abstract

Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).

Keywords: Annexin; Apoptosis; Calcium; Sarcoidosis.

Publication types

Review

MeSH terms

Animals
Annexins / chemistry
Annexins / genetics
Annexins / metabolism*
Disease Models, Animal
Humans
Models, Biological
Polymorphism, Genetic
Protein Binding
Sarcoidosis / etiology*
Sarcoidosis / metabolism*

Substances

Annexins