Killing Lymphoma with Smac-Mimetics: As Easy as ABC?

Ueli Nachbur; John Silke

doi:10.1016/j.ccell.2016.03.018

Killing Lymphoma with Smac-Mimetics: As Easy as ABC?

Cancer Cell. 2016 Apr 11;29(4):425-427. doi: 10.1016/j.ccell.2016.03.018.

Authors

Ueli Nachbur¹, John Silke²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia. Electronic address: nachbur@wehi.edu.au.
² The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.

PMID: 27070692
DOI: 10.1016/j.ccell.2016.03.018

Abstract

Smac-mimetics are compounds that target cellular Inhibitor of APoptosis (cIAP) proteins and induce tumor cell death. In this issue of Cancer Cell, Yang and colleagues (2016) identify cIAPs at the CARD11-MALT1-BCL10 complex in the ABC subtype of diffuse large B cell lymphoma (DLBCL), making this malignancy a prime target for these drugs.

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MeSH terms

Cell Line, Tumor*
Humans
Inhibitor of Apoptosis Proteins*
Lymphoma, Large B-Cell, Diffuse
NF-kappa B / metabolism

Substances

Inhibitor of Apoptosis Proteins
NF-kappa B