The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?

Biochim Biophys Acta. 2016 Aug;1857(8):1139-1146. doi: 10.1016/j.bbabio.2016.03.034. Epub 2016 Apr 9.

Abstract

The Crabtree and Warburg effects are two well-known deviations of cell energy metabolism that will be described herein. A number of hypotheses have been formulated regarding the molecular mechanisms leading to these cellular energy metabolism deviations. In this review, we will focus on the emerging notion that metabolite-induced regulations participate in the induction of these effects. All throughout this review, it should be kept in mind that no regulatory mechanism is exclusive and that it may vary in cancer cells owing to different cell types or oncogenic background. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.

Keywords: Crabtree; Glycolysis; Metabolites; Oxidative phosphorylation; Warburg.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Respiration / drug effects
  • Fructosediphosphates / metabolism
  • Fructosephosphates / metabolism
  • Glucose / metabolism*
  • Glucose / pharmacology
  • Glucose-6-Phosphate / metabolism
  • Glycolysis / drug effects*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Oxidative Phosphorylation / drug effects*
  • Oxygen / metabolism*
  • Oxygen / pharmacology
  • Oxygen Consumption / drug effects
  • Tumor Cells, Cultured

Substances

  • Fructosediphosphates
  • Fructosephosphates
  • Glucose-6-Phosphate
  • fructose-6-phosphate
  • Glucose
  • fructose-1,6-diphosphate
  • Oxygen