Ten years of HPV vaccines: State of art and controversies

Roberto Angioli; Salvatore Lopez; Alessia Aloisi; Corrado Terranova; Carlo De Cicco; Giuseppe Scaletta; Stella Capriglione; Andrea Miranda; Daniela Luvero; Roberto Ricciardi; Roberto Montera; Francesco Plotti

doi:10.1016/j.critrevonc.2016.03.020

Ten years of HPV vaccines: State of art and controversies

Crit Rev Oncol Hematol. 2016 Jun:102:65-72. doi: 10.1016/j.critrevonc.2016.03.020. Epub 2016 Apr 2.

Affiliations

¹ Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
² Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy. Electronic address: s.lopez@unicampus.it.
³ Department of Obstetrics, Gynecology, Campus Bio Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy; Unit of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Italy.

PMID: 27066937
DOI: 10.1016/j.critrevonc.2016.03.020

Abstract

The human papillomavirus (HPV) represents one of the most common sexually transmitted infections and it has been related to cervical cancer. The HPV vaccines prevent infection with certain species of HPV associated with the development of cervical cancer or genital warts. We carried out a PubMed search up to 2015 evaluating all randomized studies published in literature. This review discusses the current status of HPVs vaccines on the global market, efficacy, safety profiles, controversies and future vaccine developments. Three HPVs vaccines are currently on the global market: bivalent, quadrivalent and ninevalent. Bivalent and quadrivalent vaccines can protect against almost 70% of cervical HPV-related cancerous and precancerous conditions and the ninevalent vaccine, instead, provides a protection against almost 90%. The use of vaccinations raised several controversies in the last years and, currently, is not possible to establish which type of vaccine is most effective, however all of them are safe.

Keywords: Bivalent; HPV; Ninevalent; Quadrivalent; Vaccine.

Publication types

Review

MeSH terms

Female
Humans
Papillomavirus Infections / complications
Papillomavirus Infections / prevention & control*
Papillomavirus Vaccines / adverse effects
Papillomavirus Vaccines / therapeutic use*
Precancerous Conditions
Uterine Cervical Neoplasms / prevention & control*
Uterine Cervical Neoplasms / virology

Substances

Papillomavirus Vaccines